There are a wide range of chemicals and chemical mixtures that humans use to control plants, animals and insects. Many of these are poisons and can attack a number of physiological systems. Algaecides, Antifouling agents, Antimicrobials, Attractants, Biopesticides, Biocides Disinfectants and sanitizers, Fungicides, Fumigants, Herbicides, Insecticides, Miticides, Microbial pesticides, Molluscicides, Nematicides; Ovicides, Pheromones, Repellents, Rodenticides as well as some chemical defenses used by plants. Six biological parameters are calculated for dozens of these molecules. (GPCR ligand, Ion channel modulator, Kinase inhibitor, Nuclear receptor ligand, Protease inhibitor, Enzyme inhibitor) to help understand what impact they might have on humans and other mammals. For example, G protein-coupled receptors (GPCRs), have several names including G protein linked receptors (GPLR). They are a family of protein receptors located on the cell membrane that detect molecular species that can initiate or impact cellular responses. G protein-coupled receptors have been correlated with a large number of diseases including cancer, antibiotics, HIV and Alzheimer’s, are a target of one third of all medicinal drugs currently being utilized. This presentation will identify the best and the worst of chemicals used and make a suggestion for each to lower their negative impact.