Nurses predominantly use antiseptic hand sanitizer in place of general hand washing. However, hand sanitizers are not always the best method for controlling the spread of bacteria especially among children. Our research question states, in the pediatric units, what is the effect of hand washing with antiseptic soap on reducing health acquired infections? The use of proper hand washing techniques of healthcare workers in pediatric units are not compliant. We conducted a systematic review of the literature to answer our research question. We created a practice protocol to promote compliance of proper hand washing. This practice could help hospital reduce costs by decreasing hospital-acquired infections.